Priyadarshini Pathak

Priyadarshini Pathak
  • Faculty
  • Instructor

Education

Ph.D. Chemistry. Specialization in chemical biology, 2012
Graduate Program in Chemistry, Stony Brook ÑÇÖÞ×ÔοÊÓÆµ, Stony Brook, NY

M.Sc. Analytical Chemistry, 2001
MES’ Abasaheb Garware College, ÑÇÖÞ×ÔοÊÓÆµ of Pune, Pune, India

B.Sc. Chemistry, with Minors in: Physics, Botany and Zoology, 1999
MES’ Abasaheb Garware College, ÑÇÖÞ×ÔοÊÓÆµ of Pune, Pune, India

ÑÇÖÞ×ÔοÊÓÆµ Research/Collaboration

  • Designing lipophilic organic-salt nanoparticles for selectively targeting cancer cells.
  • Mechanism of plasma membrane interaction of lipophilic organic salt based nanoparticles.
  • Study of Nanodomain (Lipid Raft) Formation and effect of Triton X-100 and peptides on lipid raft size in Membranes.
  • Study of membrane lipid composition on formation of lipid raft nanodomains
  • Detection of membrane nanodomains in living Borrelia burgdorferi cells.
  • Determination of effect of membrane lipid composition on raft size.

Publications

  • Pathak P and London E. (2015) The Effect of Membrane Lipid Composition Upon the Formation of Lipid Ultrananodomains. Biophysical Journal 109 (8) (1630-1638).
  • Pathak P*, LaRocca TJ*, Chiantia S, Toledo A, Dastgheib-Behesti K, Silvius JR, Benach JL and London E. (* Equal contribution) (2013). Proving lipid rafts exist: membrane domains in the prokaryote Borreliaburgdorferi have the same properties as eukaryotic lipid rafts. PLOS Pathogens 9 (1-11).
  • Pathak P and London E (2011). Measurement of Lipid Nanodomain (Raft) Formation and Size in Sphingomyelin/POPC/Cholesterol Vesicles Shows TX-100 and Transmembrane Helices Increase Domain Size by Coalescing Pre-Existing Nanodomains But Do Not Induce Domain Formation. Biophysical Journal 101 (2417- 2425).
  • LaRocca TJ, Crowley JT, Cusack BJ, Pathak P, Benach J, London E, Garcia-Monco JC and Benach JL. (2010). Cholesterol lipids of Borrelia burgdorferi form lipid rafts and are required for the bactericidal activity of a complement-independent antibody. Cell Host Microbe 8 (331-342).
  • Omar Bakht, Pathak P and London E. (2007). Effect of the structure of lipids favoring disordered domain formation on the stability of cholesterol-containing ordered domains (lipid rafts): Identification of multiple raft- stabilization mechanisms. Biophysical Journal 93 (4307-4318).